Drug intelligence / Profile preview

89Zr-DFO-CN808001

Development stage
Unknown
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

89Zr-DFO-CN808001 is a radiopharmaceutical agent composed of the monoclonal antibody CN808001 conjugated to the chelator desferrioxamine (DFO) and labeled with the positron-emitting radioisotope zirconium-89 (89Zr). This type of compound is designed for use in immuno-PET imaging, enabling non-invasive visualization and quantification of specific molecular targets in vivo. The mechanism involves the antibody component binding to its target antigen on tumor cells or within tissues, while the radioactive zirconium allows for PET imaging. The DFO chelator securely binds zirconium-89, ensuring stability and effective delivery to target sites. Such agents are primarily used as diagnostic tools in oncology for tumor detection, staging, and therapy monitoring.

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