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89Zr-DFO-hu4G4
- Development stage
- Preclinical
- Lead developer
- Soochow University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**89Zr-DFO-hu4G4** is an investigational B7-H3-targeted immunoPET tracer comprising the humanized anti-B7-H3 IgG1 monoclonal antibody hu4G4 conjugated to the deferoxamine chelator and radiolabeled with positron-emitting zirconium-89. It binds extracellular B7-H3, also called CD276, enabling noninvasive PET visualization of B7-H3-expressing tumors. Preclinical studies in glioblastoma and engineered B7-H3-positive tumor models reported selective tumor uptake, prolonged tracer stability, and imaging performance supporting its potential use for tumor B7-H3-expression assessment. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/39322604/))
- Other names
- 89Zr-deferoxamine-hu4G4[89Zr]Zr-DFO-hu4G4[89Zr]Zr-desferrioxamine-hu4G4
02
Targets
B7-H3
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