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89Zr-LNCab072
- Development stage
- Phase 1
- Lead developer
- Affiliated Hospital of Jiangnan University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
89Zr-LNCab072 is a radiolabeled monoclonal antibody developed for PET imaging of HER2-positive cancers. It consists of a HER2-targeting antibody labeled with the radioactive isotope zirconium-89 (^89Zr), enabling non-invasive imaging of HER2 expression in tumors. This agent is under early-phase clinical evaluation for its ability to detect and characterize HER2-positive malignancies, including breast cancer, gastric cancer, and urothelial carcinoma, using PET/CT imaging. The primary objectives include assessing efficacy, safety, dosimetry, biodistribution, and diagnostic performance in comparison to traditional tracers such as 18F-FDG[1][3].
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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