Drug intelligence / Profile preview

89Zr-LNCab190

Development stage
Phase 1
Lead developer
Affiliated Hospital of Jiangnan University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

89Zr-LNCab190 is a diagnostic radiopharmaceutical comprising a monoclonal antibody labeled with the positron-emitting isotope zirconium-89 (89Zr). It is designed as a HER2-targeted imaging agent for use in positron emission tomography (PET) to diagnose and screen for HER2-positive malignancies. The radiolabeled antibody binds to HER2-expressing cells, allowing for visualization of HER2-positive tumors in vivo. The drug is under early-phase clinical investigation primarily as a molecular imaging agent, not as a therapeutic. The originator and main developer is the Affiliated Hospital of Jiangnan University[1][5].

Brand names
89Zr-LNCab190
02

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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