8b

8b is a preclinical α-helical antimicrobial peptide (AMP) being developed by AJK Biopharmaceutical for the treatment of Gram-negative bacterial infections. It functions as a membrane disruptor, specifically targeting and modulating the bacterial cell membrane to induce lysis and cell death. This modality is designed to combat multi-drug resistant (MDR) pathogens by utilizing a physical mechanism of action that is less prone to traditional antibiotic resistance mechanisms. The peptide is engineered to selectively interact with the negatively charged components of bacterial membranes while minimizing toxicity to mammalian cells.

Other names

8b-AJK Biopharmaceutical-Cell membrane-peptide-α-helical peptide-Gram-Negative Bacterial Infections