9-bromo-trimethoxybenzyl-noscapine

**9-bromo-trimethoxybenzyl-noscapine** is a **synthetic analogue** of noscapine, designed by structurally modifying the natural alkaloid noscapine, typically by introducing a bromine atom at the 9-position and a trimethoxybenzyl group to enhance cytotoxic and microtubule-modulating activity. These analogues are part of the noscapinoids, a class of tubulin-binding agents derived from noscapine, which itself is a non-toxic phthalideisoquinoline alkaloid obtained from the opium poppy. The mechanism of action for these compounds centers on **binding to the colchicine site of tubulin** and modulating microtubule dynamics, thereby **inducing cell-cycle arrest (especially G2/M phase) and cytotoxic activity** against various cancer cell lines, including prostate, breast, and pancreatic carcinomas[1][3][4]. These derivatives are developed to improve anticancer potency and pharmacological properties, such as oral bioavailability and reduced toxicity, compared to traditional microtubule-targeting drugs.

Other names

9-bromo-trimethoxybenzyl-noscapine