9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine

9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine is a synthetic small molecule belonging to the class of purine-based compounds. It acts as an inhibitor of the molecular chaperone heat shock protein HSP90 (specifically HSP90-alpha), which is involved in the folding and stabilization of many client proteins critical for cancer cell survival. By inhibiting HSP90's ATPase activity at its N-terminal domain, this compound disrupts the function of oncogenic client proteins such as Raf‑1 kinase and ErbB2/HER2. This mechanism has been explored as a potential anticancer strategy in preclinical research settings[4][6]. The compound is experimental and not approved for clinical use.

Other names

9-butyl-8-(2,5-dimethoxy-benzyl)-9h-purin-6-ylamine9-butyl-8-[(2,5-dimethoxyphenyl)methyl]-9H-purin-6-aminePurine-Based Inhibitor 5