9-butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine

**Description:** 9-butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylaMine (PU8) is a synthetic small molecule belonging to the class of purine-based compounds known as 6‑aminopurines. It functions as an experimental inhibitor of the molecular chaperone heat shock protein HSP90-alpha. By binding to the N-terminal ATP-binding domain of HSP90-alpha and inhibiting its ATPase activity, PU8 disrupts the function of HSP90 and leads to degradation or downregulation of client proteins such as Raf‑1 kinase and ErbB2. This mechanism results in inhibition of cell growth and has been explored as a potential antineoplastic (anticancer) strategy in preclinical research[2][3][4]. The compound is not approved for clinical use.

Other names

9-butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylaMine9-butyl-8-(2-chloro-3,4,5-trimethoxyphenyl)methyl)-9H-purin-6-amIneDB03504DB-03504DB 03504