9-deazahypoxanthine

9-Deazahypoxanthine is a synthetic small molecule analog of hypoxanthine in which the nitrogen at position 9 of the purine ring is replaced by carbon. It belongs to the class of pyrrolopyrimidines and has been studied primarily as a research tool and as a scaffold for drug development. Derivatives and analogs of this compound have shown activity as inhibitors of purine nucleoside phosphorylase (PNP) and hypoxanthine–guanine–xanthine phosphoribosyltransferase (HGXPRT), enzymes involved in purine metabolism. These properties make it relevant for potential use as an immunosuppressive agent or antitumor agent. Some derivatives are under investigation for selective inhibition against Plasmodium falciparum HGXPRT (malaria target) over human HGPRT. The parent compound itself is not approved for clinical use but serves as a lead structure in medicinal chemistry research targeting cancer, autoimmune diseases (such as T-cell leukemia/lymphoma), and infectious diseases like malaria[1][2][4][5].

Other names

3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one1H-pyrrolo[3,2-d]pyrimidin-4(5H)-oneMFCD09832196MFCD-09832196MFCD 09832196DTXSID60971989DTXSID-60971989DTXSID 60971989