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Drug intelligence / Profile preview
9-ethyl-8-iodo-2-phenethoxy-9h-purin-6-amine
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
**9-ethyl-8-iodo-2-phenethoxy-9h-purin-6-amine** is a synthetic **adenine derivative** evaluated as a **A2A adenosine receptor antagonist**[1]. It is part of a series of 2,8-disubstituted adenines developed to selectively bind and block the A2A adenosine receptor with high affinity (low nanomolar Ki), displaying functional antagonist activity in both in vitro and in vivo models[1]. In rat models of Parkinson’s disease, it reversed haloperidol-induced catalepsy and enhanced levodopa-induced contralateral rotation (consistent with anti-parkinsonian activity)[1]. Its structure features an ethyl group at N9, an iodine atom at C8, and a phenethoxy group at C2 of the purine scaffold, conferring selectivity and potency. There is no evidence it is marketed or has code names, and it appears to be in early-phase, preclinical research and not associated with any pharmaceutical company as a development candidate.
- Other names
- 9-ethyl-8-iodo-2-phenethoxy-9h-purin-6-amine
02
Targets
ADORA2A (Adenosine A₂A Receptor)
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