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99mTc-BBN

Development stage: Preclinical
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

99mTc-BBN is a radiopharmaceutical composed of the gamma-emitting radionuclide technetium-99m (99mTc) conjugated to a bombesin (BBN) peptide derivative. It specifically targets the gastrin-releasing peptide receptor (GRPR), which is highly expressed in several human tumors, including prostate, breast, and gastrointestinal cancers. While primarily utilized as a diagnostic imaging agent for Single Photon Emission Computed Tomography (SPECT), 99mTc-BBN is also studied in the context of targeted radionuclide therapy due to the emission of Auger electrons by 99mTc. In comparative studies, it serves as a reference compound for evaluating the efficacy of multi-targeted radioconjugates designed to enhance intracellular irradiation of sensitive organelles like the nucleus or mitochondria.

Other names: 99mTc-bombesinTechnetium-99m bombesinTechnetium99m bombesinTechnetium 99m bombesin

Targets

GRPR (Gastrin-releasing peptide receptor)αVβ3 (Integrin αVβ3)

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