Drug intelligence / Profile preview

99mTc-EDDA-KL01099

Development stage: Unknown
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

99mTc-EDDA-KL01099 is an experimental **PSMA-targeted radiopharmaceutical** imaging agent for prostate cancer detection by SPECT. It is a **technetium-99m-labeled small-molecule tracer** built on a Lys-urea-Glu PSMA-binding pharmacophore conjugated to a HYNIC chelator and formulated with EDDA as a co-ligand for technetium coordination. In preclinical studies, the tracer bound PSMA-expressing cells with nanomolar affinity and visualized PSMA-positive prostate cancer xenografts in SPECT imaging, but also showed relatively high renal and splenic uptake. Based on the provided literature context, it appears to be a research-stage academic radiotracer rather than a commercial product, investigated for molecular imaging of prostate cancer lesions.

Other names: technetium-99m EDDA-KL01099technetium99m EDDA-KL01099technetium 99m EDDA-KL0109999mTc-labeled KL01099

Targets

PSMA (Prostate-specific membrane antigen)

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