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99mTc-HYNIC liposome
- Development stage
- Preclinical
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
99mTc-HYNIC liposome is a diagnostic radiopharmaceutical imaging agent consisting of liposomal nanoparticles labeled with the radioisotope technetium-99m (99mTc). The formulation utilizes hydrazinonicotinic acid (HYNIC) as a bifunctional chelator, often conjugated to a lipid such as stearyl 6-(benzylidenehydrazinyl) nicotinamide, to stably anchor the 99mTc isotope to the liposome structure. These agents are designed to accumulate in tumor tissues via the enhanced permeability and retention (EPR) effect, enabling non-invasive scintigraphic imaging to assess tumor development and permeability. This information can be used for personalized chemotherapy planning and monitoring treatment response.
- Other names
- 99mTc-labeled HYNIC liposome99mTc-HYNIC-PEG liposometechnetium Tc 99m HYNIC liposome
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