99mTc-HYNIC-PEG liposome

99mTc-HYNIC-PEG liposome is a **radiolabeled PEGylated liposome** in which the liposome membrane incorporates a hydrazino-nicotinyl (HYNIC) derivative as a chelator, enabling rapid and stable labeling with the gamma-emitting radionuclide technetium-99m (99mTc)[1][3]. The addition of a polyethylene glycol (PEG) layer increases circulation time and reduces uptake by the reticuloendothelial system. This compound is primarily developed as a **radiopharmaceutical for SPECT imaging**, particularly to track the in vivo distribution and localization of liposomal drug formulations and as an infection imaging agent. The 99mTc-HYNIC labeling method offers higher efficiency and stability than prior methods, facilitating clinical workflow and enhancing image quality[1][3]. PEGylated formulations exhibit improved tumor or infection site localization via the enhanced permeability and retention effect, making them valuable for noninvasive monitoring of drug delivery and disease localization.

Other names

technetium-99m HYNIC PEGylated liposometechnetium99m HYNIC PEGylated liposometechnetium 99m HYNIC PEGylated liposomeTc-99m-HYNIC-PEG-liposomeTc99m-HYNIC-PEG-liposomeTc 99m-HYNIC-PEG-liposome