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99mTc-HYNIC-RGD
- Development stage
- Unknown
- Lead developer
- Instituto Nacional de Cancerologia de Mexico
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
99mTc-HYNIC-RGD is a technetium-99m labeled radiopharmaceutical consisting of a cyclic RGD (arginine-glycine-aspartate) peptide conjugated to the bifunctional chelator hydrazinonicotinamide (HYNIC). It is designed as a single-photon emission computed tomography (SPECT) imaging agent that targets integrin αvβ3, which is highly expressed on angiogenically active endothelial cells and various tumor cells. By binding to integrin αvβ3, 99mTc-HYNIC-RGD allows for the non-invasive visualization and quantification of tumor angiogenesis and integrin expression, particularly in cancers such as locally advanced breast cancer, glioma, and lung cancer.
- Other names
- 99mTc-EDDA/HYNIC-RGD99mTc-HYNIC-D(RGD)99mTc-HYNIC-beta-Ala-RGD99mTc-HYNIC-c(RGDfK)99mTc-HYNIC-c(RGDyK)99mTc-tricine-HYNIC-RGD
02
Targets
αVβ3 (Integrin αVβ3)
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