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99mTc-leu13-BN1
- Development stage
- Unknown
- Lead developer
- Instituto Nacional de Investigaciones Nucleares
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
**99mTc-leu13-BN1** is a technetium-99m-labelled [Leu13] bombesin-like peptide developed as a SPECT scintigraphic radiopharmaceutical for imaging malignancies that express bombesin receptors. The tracer binds bombesin-family receptors, particularly the gastrin-releasing peptide receptor, enabling rapid localization of receptor-positive tumors and lymph-node disease. Clinical publications reported imaging studies in breast, colorectal, pancreatic, prostate, and small-cell lung cancers, as well as gastrinoma; a colorectal-cancer study reported high lesion sensitivity but limited specificity.
- Other names
- 99mTc [13Leu] bombesin99mTc BN199mTc-bombesin99mTc-leu13-BN1technetium [Leu13] bombesin
02
Targets
NMBR (Neuromedin B receptor)BRS3 (Bombesin receptor subtype 3)GRPR (Gastrin-releasing peptide receptor)
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