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99mTc-liposomal amphotericin B
- Development stage
- Unknown
- Lead developer
- Radboud University Medical Center
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Inhalation
01
Overview
99mTc-liposomal amphotericin B is an investigational inhaled SPECT/CT imaging tracer in which liposomal amphotericin B is labeled with technetium-99m. It is being used by Radboud University Medical Center to quantify lung deposition and intrapulmonary distribution after nebulization in people with chronic pulmonary aspergillosis, including comparison of pulmonary deposition with systemic amphotericin B exposure. It is a radiolabeled investigational version of liposomal amphotericin B intended for imaging drug delivery rather than for standalone antifungal treatment. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07530263))
- Other names
- technetium-99m-labeled liposomal amphotericin Btechnetium99m-labeled liposomal amphotericin Btechnetium 99m-labeled liposomal amphotericin B
02
Targets
Ergosterol
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