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99mTc-MAG3-BIIB067

Development stage: Unknown
Lead developer: Biogen
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intrathecal

Overview

99mTc-MAG3-BIIB067 is a radiolabeled version of tofersen (BIIB067), an antisense oligonucleotide that targets the SOD1 gene. It is used in clinical studies to evaluate the distribution of tofersen in the central nervous system (CNS). The compound consists of tofersen labeled with technetium-99m (99mTc) using MAG3 (mercaptoacetyltriglycine) as a chelating agent. This radiolabeled version allows for tracking the distribution of the drug using SPECT/CT imaging techniques.

Targets

SOD (Manganese Superoxide Dismutase)

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