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99mTc-MIRC213

Development stage: Phase 1
Lead developer: Peking Union Medical College Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

99mTc-MIRC213 is a radiopharmaceutical diagnostic imaging agent developed by Peking Union Medical College Hospital for the detection of HER2-positive breast cancer. It consists of the radionuclide Technetium-99m (99mTc) conjugated to MIRC213, a targeting moiety that specifically binds to the Human Epidermal Growth Factor Receptor 2 (HER2). The agent is utilized in Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) to non-invasively assess HER2 expression levels in primary and metastatic breast cancer lesions, facilitating the selection of patients for HER2-targeted treatments.

Other names: 99mTc-labeled MIRC213

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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