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99mTc-nano-graphene oxide-polyethylene glycol-folic acid

Development stage: Preclinical
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

**99mTc-nano-graphene oxide-polyethylene glycol-folic acid** is an experimental, folate receptor-targeted SPECT molecular-imaging probe. It consists of nanosized graphene oxide covalently functionalized with polyethylene glycol and folic acid, then directly radiolabeled with technetium-99m. Folic acid is intended to promote accumulation in folate receptor-expressing tumor cells, while the technetium-99m label enables gamma-camera and SPECT detection. The probe was evaluated following intravenous administration in Patu8988 human pancreatic-cancer xenograft-bearing nude mice, where tumors were visibly imaged at approximately 4 to 6 hours after injection. It is an academic preclinical imaging construct, with no identified commercial developer, brand name, regulatory approval, or registered clinical development program. ([journals.sagepub.com](https://journals.sagepub.com/doi/pdf/10.1089/cbr.2017.2395))

Other names: 99mTc-nGO-PEG-FA

Targets

FOLR1 (FRα)

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