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99mTc-NS654
- Development stage
- Preclinical
- Lead developer
- Charles University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
99mTc-NS654 is a novel technetium-99m labeled radioligand based on an alpha-ketoamide fibroblast activation protein (FAP) inhibitor. Developed by Charles University and the Czech Academy of Sciences, it is designed for targeting and imaging FAP-expressing tumors, particularly brain metastases. In preclinical studies, 99mTc-NS654 demonstrated specific binding to FAP-expressing cells, efficient internalization, and favorable pharmacokinetics. Crucially, it has been shown to cross the blood-tumor barrier and selectively accumulate in intracranial tumors, supporting its potential use as a diagnostic SPECT imaging agent for brain metastases.
- Other names
- 99mTc-labelled NS654technetium-99m NS654technetium99m NS654technetium 99m NS654
02
Targets
FAP (Fibroblast activation protein alpha)
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