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99mTc-PR1A3

Development stage: Unknown
Lead developer: St. Mark’s Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

99mTc-PR1A3 is a radiopharmaceutical composed of the murine monoclonal antibody PR1A3, which targets a normal colonic columnar cell surface antigen, labeled with technetium-99m (99mTc), a widely used gamma-emitting radionuclide. The primary application of 99mTc-PR1A3 is in radioimmunoscintigraphy for imaging colorectal cancer. The antibody specifically binds to carcinoembryonic antigen (CEA) expressed on colorectal carcinoma cells, allowing for targeted imaging due to high tumor-to-mucosa uptake ratios. This agent enables rapid and routine nuclear medicine studies for the detection and management of colorectal cancer[1][5]. Mechanistically, it combines the specificity of monoclonal antibody targeting with the diagnostic capabilities of radiolabeled imaging agents.

Other names: technetium-99m PR1A3technetium99m PR1A3technetium 99m PR1A3Tc-99m PR1A3Tc99m PR1A3Tc 99m PR1A3

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