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99mTc-SSS Lipiodol UltraFluid

Development stage
Unknown
Lead developer
Centre Eugene Marquis
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intra-arterial
01

Overview

**99mTc-SSS Lipiodol UltraFluid** is an investigational technetium-99m radiolabeled iodized-oil preparation developed as a biodistribution and potential pretherapeutic imaging surrogate for radiolabeled Lipiodol-based intra-arterial therapy of hepatocellular carcinoma. It consists of a lipophilic technetium-99m Super Six Sulfur complex dissolved in Lipiodol UltraFluid, an iodized poppy-seed oil. Following hepatic arterial administration, the oily radiotracer preferentially deposits in hypervascular liver tumors and can be measured by gamma imaging or gamma counting. In rat hepatocellular carcinoma experiments, stabilized water-in-oil and oil-in-water emulsions of this agent did not improve tumor targeting and instead reduced tumor uptake in several tested formulations.

Other names
99mTc-SSS LUF99mTc-SSS Lipiodol99mTc-SSS-lipiodoltechnetium Tc 99m-labeled Super Six Sulfur Lipiodol UltraFluid

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