Drug intelligence / Profile preview

99mTc-tricine-HYNIC-SSS-GE11

Development stage: Preclinical
Lead developer: Tehran University of Medical Sciences
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

99mTc-tricine-HYNIC-SSS-GE11 is a radiolabeled peptide-based diagnostic imaging agent being investigated for the detection of ovarian cancer and other tumors that overexpress the epidermal growth factor receptor (EGFR). The compound consists of the GE11 peptide, a dodecapeptide (YHWYGYTPQNVI) that binds specifically to EGFR, conjugated to a 6-hydrazinonicotinic acid (HYNIC) chelator via a tri-serine (SSS) linker. It is radiolabeled with technetium-99m (99mTc) using tricine as a coligand to form a stable complex suitable for single-photon emission computed tomography (SPECT) imaging. Preclinical evaluations have demonstrated high radiochemical purity, stability in human serum, and high affinity for EGFR-expressing cells, suggesting its potential as a non-invasive molecular probe for early cancer diagnosis.

Other names: 99mTc-HYNIC-SSS-GE1199mTc-labeled GE11 peptide

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)

Beyond the preview

Go deeper on 99mTc-tricine-HYNIC-SSS-GE11.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 99mTc-tricine-HYNIC-SSS-GE11.

Explore the full profile