Drug intelligence / Profile preview

99mTc-UBI 29-41

Development stage
Unknown
Lead developer
Leiden University Medical Center
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Peptides
Administration
Intravenous
01

Overview

99mTc-UBI 29-41 is a technetium-99m labeled synthetic peptide fragment of the human/murine antimicrobial peptide ubiquicidin (specifically residues 29-41, sequence TGRAKRRMQYNRR). It is a cationic peptide that preferentially binds to the anionic cell membranes of viable bacteria and fungi at the site of infection, allowing for the differentiation of bacterial/fungal infections from sterile inflammation. It is used as a diagnostic radiopharmaceutical for SPECT (single-photon emission computed tomography) imaging of various musculoskeletal infections, osteomyelitis, prosthetic joint infections, and diabetic foot infections.

Other names
99mTc-UBI99mTc-ubiquicidin (29-41)99mTc-ubiquicidin 29-41technetium (99mTc) ubiquicidin (29-41)technetium Tc 99m ubiquicidin (29-41)

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