Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
9D8 CAR-T
- Development stage
- Preclinical
- Lead developer
- Tongji University
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
9D8 CAR-T is an experimental chimeric antigen receptor (CAR) T-cell therapy utilizing a nanobody-derived (VHH) binding domain specific for CD70. Developed for the treatment of renal cell carcinoma (RCC), the 9D8 clone was selected from alpaca immunization for its high affinity and specificity. Unlike traditional scFv-based CARs, the nanobody-based 9D8 CAR-T cells demonstrate enhanced cytokine production (IL-2, IFN-γ, TNF-α) and robust anti-tumor activity in xenograft models, including the ability to resist tumor re-challenge. The therapy aims to provide a long-lasting anti-tumor response by targeting CD70, which is highly expressed in RCC and associated with poor survival.
- Other names
- anti-CD70 9D8 CAR-Tanti-CD-70 9D8 CAR-Tanti-CD 70 9D8 CAR-T9D8-CAR-T
02
Targets
CD70 (Cluster of Differentiation 70)
Beyond the preview
Go deeper on 9D8 CAR-T.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 9D8 CAR-T.