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Drug intelligence / Profile preview
açai extract
- Development stage
- Unknown
- Lead developer
- Federal University of São Paulo
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Açai extract is a botanical extract derived from the fruit of the açai palm (*Euterpe oleracea*), native to the Amazon region. It is rich in bioactive phytochemicals, particularly polyphenols and anthocyanins (such as cyanidin-3-glucoside and cyanidin-3-rutinoside), which confer potent antioxidant and anti-inflammatory properties. The extract acts primarily by modulating the NLRP3 inflammasome pathway, inhibiting NF-kB activation, and activating the Nrf2 antioxidant response. Açai extract has been investigated in clinical and preclinical studies for various conditions, including COVID-19 (where it was evaluated in a Phase 2 trial to mitigate hyperinflammation), diabetic nephropathy, endometriosis, and cardiovascular diseases.
- Other names
- Euterpe oleracea extractEuterpe oleracea fruit extractaçai berry extractaçai palm berry extract
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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