A-205804

A-205804 is a potent and selective small molecule inhibitor of E-selectin and intercellular adhesion molecule-1 (ICAM-1) expression.[1][3] The compound functions as an inhibitor of cell adhesion molecules that mediate endothelial-leukocyte interactions essential in inflammatory responses.[1] Mechanistically, A-205804 translocates to the nucleus and binds non-covalently to large molecular targets (>650 kDa).[1] It is orally bioavailable and serves as a research tool for studying inflammatory processes and adhesion-associated diseases, including potential applications in cancer research and neuropathic pain models.[2][4]

Other names

4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide