A-443654

A‑443654 is a synthetic small molecule inhibitor of the serine/threonine kinase Akt, also known as protein kinase B. It is an indole-based compound developed for research purposes and has been widely used as a tool compound to study the PI3K/Akt signaling pathway. By inhibiting Akt, A‑443654 blocks downstream signaling involved in cell survival, proliferation, and metabolism. This makes it valuable for investigating cancer biology and other diseases where Akt plays a critical role. The compound is primarily used in preclinical studies and has not advanced to clinical development or approval for therapeutic use[2][4][5].

Other names

(2S)-1-(1H-indol-3-yl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine(2S)-1-(1H-Indol-3-YL)-3-{[5-(3-methyl-1H-indazol-5-YL)pyridin-3-YL]oxy}propan-2-amino552325–16–3