Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
A3AR siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Intraperitoneal, Parenteral
01
Overview
A3AR siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Adenosine A3 Receptor (A3AR/ADORA3). In biomedical research, particularly in studies of ulcerative colitis (UC), A3AR siRNA is utilized as a tool to investigate the receptor's role in regulating intestinal epithelial cell pyroptosis. Experimental evidence indicates that silencing A3AR increases the activation of Gasdermin D (GSDMD), NLRP3, and caspase-1, thereby promoting the release of pro-inflammatory cytokines like IL-1β and IL-18. This suggests that A3AR signaling normally serves to inhibit GSDMD-mediated pyroptosis, highlighting the receptor as a potential therapeutic target for inflammatory bowel diseases.
- Other names
- adenosine A3 receptor siRNAADORA3 siRNAADORA-3 siRNAADORA 3 siRNA
02
Targets
ADORA3 (Adenosine A3 receptor)
Beyond the preview
Go deeper on A3AR siRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on A3AR siRNA.