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A7-FML
- Development stage
- Preclinical
- Lead developer
- Kyoto Prefectural University of Medicine
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
A7-FML is an investigational **magnetic resonance imaging contrast agent** comprising murine monoclonal antibody A7 coupled to ferromagnetic lignosite particles. The A7 antibody binds the colorectal cancer-associated antigen A7, promoting preferential accumulation of the iron oxide-containing particles in colorectal carcinoma xenografts; the magnetic particles reduce tumor MRI signal intensity and enable targeted lesion visualization. Public evidence is limited to in-vitro and nude-mouse xenograft studies in human colorectal carcinoma models. ([ncbi.nlm.nih.gov](https://www.ncbi.nlm.nih.gov/books/NBK23104/))
- Other names
- A7-FMLA-7-FMLA 7-FMLmonoclonal antibody against antigen A7 coupled to ferromagnetic lignosite particles
02
Targets
Antigen A7 (Colorectal cancer-associated antigen A7)
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