Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
AA98
- Development stage
- Preclinical
- Lead developer
- MicroConstants
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
AA98 is a monoclonal antibody targeting CD146, a cell adhesion molecule also known as melanoma cell adhesion molecule (MCAM) or MUC18. CD146 is a novel drug target implicated as a co-receptor of VEGF and is involved in angiogenesis and tumor progression. The AA98 antibody blocks CD146 functions, inhibiting tumor growth and angiogenesis. It has shown synergistic anti-tumor and antiangiogenic effects, especially in preclinical models of triple-negative breast cancer, and has been studied for uses in various tumors, multiple sclerosis, and age-related macular degeneration. The drug was developed originally by Prof. Yan Xiyun at the Institute of Biophysics, Chinese Academy of Sciences. MicroConstants China holds global development rights for AA98 antibody drug candidates[1][2].
- Other names
- AA98 antibodyAA-98 antibodyAA 98 antibody
02
Targets
MCAM
Beyond the preview
Go deeper on AA98.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on AA98.