AAC2-insulin

AAC2-insulin is an experimental **AAC2-human insulin complex** in which human insulin is adsorbed onto positively charged self-assembling AAC2 dipeptide nanofibers. AAC2 provides insulin-independent metabolic activity through leptin receptor-associated signaling, while the insulin component activates insulin receptor signaling; the nanofiber complex is intended to improve insulin exposure and glucose regulation while reducing hypoglycemia. In mouse models of type 1 diabetes and early Alzheimer’s disease-related pathology, AAC2-hINS improved circulating and brain insulin exposure, glycemic and cognitive outcomes, and survival relative to free insulin in reported experiments. It remains an academic, preclinical research program without a marketed product or assigned INN. ([mdpi.com](https://www.mdpi.com/1999-4923/14/1/81))

Other names

AAC2 + hINSAAC2-bound human insulinAAC-2-bound human insulinAAC 2-bound human insulinAAC2-hINSAAC-2-hINSAAC 2-hINSAAC2-insulinAAC-2-insulinAAC 2-insulin