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AAN-12x
- Development stage
- Preclinical
- Lead developer
- Aanastra
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Peptides, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
01
Overview
**AAN-12x** is a preclinical RNA-based oncology therapeutic program developed by Divincell and Aanastra for tumors carrying oncogenic **KRAS G12D, G12V, or G12C** mutations. It uses the PEP-NP peptide-nanoparticle delivery system to deliver KRAS-directed guide RNA together with CRISPR-Cas9 RNA, with the intended effect of selectively editing or silencing mutant KRAS drivers in cancer cells. The program is being explored for KRAS-mutant solid tumors, including lung cancer, colorectal cancer, and pancreatic cancer.
- Other names
- ONCOEDIT
02
Targets
KRASG12C (Kirsten rat sarcoma viral oncogene homolog G12C)KRASG12V (KRAS G12V)KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)
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