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AAV-CDH1
- Development stage
- Preclinical
- Lead developer
- Baylor College of Medicine
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies
- Administration
- Intraductal
01
Overview
AAV-CDH1 is an adeno-associated virus (AAV) vector designed for CRISPR/Cas9-mediated gene editing, specifically targeting the CDH1 gene which encodes the cell-cell adhesion protein E-cadherin. In preclinical research, it is used to induce somatic loss of E-cadherin in mammary epithelial cells, typically via intraductal administration in rat models. This loss of CDH1 is a defining genetic event in the development of invasive lobular carcinoma (ILC). AAV-CDH1 is often employed in combination with other oncogenic drivers, such as PIK3CA mutations, to create clinically relevant, estrogen receptor-positive (ER+) models of breast cancer for studying tumor biology and testing therapeutic interventions.
- Other names
- AAV-sgRNA-CDH1AAV-sgRNA-CDH-1AAV-sgRNA-CDH 1AAV-sgCDH1AAV-sgCDH-1AAV-sgCDH 1
02
Targets
CDH1 (Cadherin-1)
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