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AAV-DIO-NR5A1-OE
- Development stage
- Preclinical
- Lead developer
- UT Southwestern Medical Center
- Modality
- Gene Therapies
- Administration
- Parenteral
01
Overview
AAV-DIO-NR5A1-OE is a genetically engineered adeno-associated virus (AAV) vector designed for Cre-dependent overexpression of nuclear receptor subfamily 5 group A member 1 (NR5A1, also known as steroidogenic factor-1 or SF-1). It is used as a preclinical research tool to selectively overexpress NR5A1 in specific neuronal populations, such as the dorsomedial and central parts of the ventromedial hypothalamic nucleus (VMHdm/c) in Cre-expressing mouse models (e.g., Sf-1-BAC-Cre mice). In preclinical studies, VMHdm/c overexpression of NR5A1 mediated by this vector has been shown to improve body weight and insulin resistance in high-fat diet-induced obesity models, highlighting its role in regulating energy homeostasis and glucose metabolism.
- Other names
- AAV-DIO-NR5A1AAV-DIO-NR-5A1AAV-DIO-NR 5A1AAV-DIO-SF-1AAV-DIO-SF1AAV-DIO-SF 1
02
Targets
AMH (Anti-Müllerian hormone)CTNNB1 (Beta-catenin)NOTCH (Neurogenic locus notch homolog protein 3)NR5A1 (Steroidogenic factor 1)SOX9 (SRY-box transcription factor 9)STAR (Steroidogenic acute regulatory protein)Wnt (Wnt ligand)
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