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AAV-FAIM-L
- Development stage
- Preclinical
- Lead developer
- CIBERNED
- Modality
- Gene Therapies
- Administration
- Parenteral
01
Overview
AAV-FAIM-L is an adeno-associated virus (AAV)-based gene therapy designed to overexpress the long isoform of Fas Apoptosis Inhibitory Molecule (FAIM-L) specifically in neurons. FAIM-L is a neuron-specific anti-apoptotic protein that plays a critical role in maintaining synaptic plasticity, preventing dendritic spine loss, and promoting neuronal survival. It acts by stabilizing the X-linked inhibitor of apoptosis protein (XIAP), which in turn regulates caspase-3 activity. In neurodegenerative conditions such as Alzheimer's disease and other tauopathies, FAIM-L levels are significantly reduced, preceding tau pathology and driving synaptic dysfunction. Developed by academic researchers at the Universitat Autònoma de Barcelona and the University of Barcelona, AAV-FAIM-L is being investigated in preclinical models of Alzheimer's disease and tauopathy to restore FAIM-L levels, protect synaptic integrity, and improve cognitive and memory functions.
- Other names
- AAV9-CamKII-FAIM-LAAV-9-CamKII-FAIM-LAAV 9-CamKII-FAIM-LAAV:FAIM-L
02
Targets
CASP3 (Caspase-3)FASN (Fatty acid synthase)XIAP
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