AAV-Osm

AAV-Osm is an adeno-associated virus (AAV) gene therapy vector designed to mediate the overexpression of Oncostatin M (OSM), a cytokine belonging to the Interleukin-6 (IL-6) family. In preclinical research, AAV-Osm is utilized to investigate the systemic and local effects of chronic OSM elevation, which is associated with conditions such as cancer cachexia, musculoskeletal diseases, and inflammatory disorders. The vector delivers the OSM gene to host cells, leading to the secretion of the cytokine and subsequent activation of the Oncostatin M receptor (OSMR) and GP130 (IL6ST) signaling pathways. Studies using AAV-Osm have demonstrated that sustained OSM expression induces significant muscle atrophy, systemic bone loss, tissue fibrosis, and cardiac dysfunction (including reduced ejection fraction), independent of IL-6 signaling.

Other names

AAV-Oncostatin Madeno-associated virus-Oncostatin MAAV-mOSM