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AAV-shHDAC5
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intracerebral
01
Overview
AAV-shHDAC5 is an experimental gene therapy construct designed to knock down the expression of Histone Deacetylase 5 (HDAC5) using an adeno-associated virus (AAV) vector to deliver short hairpin RNA (shRNA). In preclinical research, specifically in models of Opioid Use Disorder (OUD), this construct is used to investigate the role of HDAC5 in the nucleus accumbens (NAc) during heroin self-administration and subsequent relapse. By reducing HDAC5 levels, the therapy modulates the expression of ion transport genes and suppresses the firing rates of medium spiny neurons (MSNs). This epigenetic intervention aims to limit the triggers for drug-seeking behavior and reduce relapse vulnerability, highlighting HDAC5 as a potential therapeutic target for substance use disorders.
- Other names
- AAV-shRNA-HDAC5AAV-shRNA-HDAC-5AAV-shRNA-HDAC 5AAV-shHdac5AAV-shHdac-5AAV-shHdac 5
02
Targets
HDAC5 (Histone deacetylase 5)
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