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AAV2-shChi3l1
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies
- Administration
- Intravenous
01
Overview
AAV2-shChi3l1 is an adeno-associated virus serotype 2 (AAV2) vector-based gene therapy designed to deliver short hairpin RNA (shRNA) targeting Chitinase-3-like protein 1 (CHI3L1). CHI3L1, also known as YKL-40, is a secreted glycoprotein that plays a significant role in inflammation, tissue remodeling, and cancer progression. In the context of hepatocellular carcinoma (HCC), CHI3L1 is induced in pulmonary epithelial cells by tumor-derived exosomes, facilitating the formation of a pre-metastatic niche in the lungs by promoting angiogenesis and cell migration. AAV2-shChi3l1 mediates the knockdown of CHI3L1 expression, thereby disrupting the establishment of this niche and significantly reducing pulmonary metastasis.
- Other names
- AAV2-shCHI3L1AAV-2-shCHI3L1AAV 2-shCHI3L1AAV2-shRNA-Chi3l1AAV-2-shRNA-Chi3l1AAV 2-shRNA-Chi3l1
02
Targets
HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))CHI3L1 (Chitinase-3-like protein 1)
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