Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
AAV6-Postn-Cre
- Development stage
- Preclinical
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Intravenous, Intraperitoneal
01
Overview
AAV6-Postn-Cre is a recombinant gene therapy vector utilizing the Adeno-Associated Virus serotype 6 (AAV6) capsid to deliver the Cre recombinase gene. Expression of the transgene is driven by the Periostin (Postn) promoter, which is highly specific to activated fibroblasts and hepatic stellate cells (HSCs). This tool is primarily employed in preclinical research using 'Cre-loxP' mouse models to achieve cell-type-specific genetic manipulation. By targeting myofibroblasts, researchers can delete or activate specific genes (such as NFIB or CCL5) to investigate their roles in the pathogenesis of organ fibrosis, including liver fibrosis associated with metabolic dysfunction-associated steatohepatitis (MASH) and cardiac fibrosis.
- Other names
- AAV6-Periostin-CreAAV-6-Periostin-CreAAV 6-Periostin-CreAAV6-Postn-iCreAAV-6-Postn-iCreAAV 6-Postn-iCrerAAV6-Postn-CrerAAV-6-Postn-CrerAAV 6-Postn-Cre
02
Targets
DNA
Beyond the preview
Go deeper on AAV6-Postn-Cre.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on AAV6-Postn-Cre.