Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
AAV8-mF8
- Development stage
- Preclinical
- Lead developer
- Queen's University
- Modality
- Gene Therapies
- Administration
- Intravenous
01
Overview
AAV8-mF8 is a recombinant adeno-associated virus serotype 8 (AAV8) gene therapy vector encoding murine coagulation factor VIII (mF8). Developed at Queen's University, it serves as a preclinical research tool to evaluate gene therapy strategies for hemophilia A in mouse models, such as F8 knock-out (F8KO) mice. The vector is designed to deliver a codon-optimized mF8 transgene to hepatocytes, enabling the expression and secretion of functional murine factor VIII to restore hemostasis. In research settings, AAV8-mF8 has been utilized to investigate the transcriptional efficiency, durability, and potential of various regulatory elements, including native F8 enhancers and liver-specific promoters, to overcome the decline in transgenic expression typically observed after vector delivery.
- Other names
- AAV8-mF8 vectorAAV-8-mF8 vectorAAV 8-mF8 vectorAAV8-mFVIIIAAV-8-mFVIIIAAV 8-mFVIIIAAV8-mFVIII vectorAAV-8-mFVIII vectorAAV 8-mFVIII vector
02
Targets
F8 (Coagulation Factor VIIIa)
Beyond the preview
Go deeper on AAV8-mF8.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on AAV8-mF8.