AAV8-renin

AAV8-renin (also referred to as ReninAAV or AAV2/8-mRen1d) is an experimental gene therapy that uses an adeno-associated virus serotype 8 (AAV8) vector to deliver and overexpress the renin gene in vivo. The construct typically employs a liver-specific promoter to drive high levels of circulating renin independent of normal physiological regulation. This approach is used primarily in preclinical research to induce persistent hypertension and model hyperactivity of the renin-angiotensin system (RAS) in rodents. Overexpression of the renin gene via this vector leads to increased plasma renin activity, elevated angiotensin II and aldosterone levels, sustained hypertension, and associated renal and cardiac pathologies. The main application is as a tool for studying RAS-driven diseases such as hypertension and diabetic nephropathy[1][2]. There are no known commercial developers or manufacturers; it is used by academic laboratories for disease modeling.

Other names

adeno-associated virus 8 renin gene therapy