AAV9-Gcgr-shRNA

AAV9-Gcgr-shRNA is a preclinical research tool consisting of an adeno-associated virus serotype 9 (AAV9) vector engineered to deliver a short hairpin RNA (shRNA) targeting the mouse glucagon receptor (Gcgr) gene. Developed as a gene-silencing biologic, it utilizes RNA interference (RNAi) to knock down the expression of the glucagon receptor in vivo. In research settings, it has been used to investigate the role of GCGR signaling in conditions such as intestinal fibrosis and chronic colitis. The vector is typically administered via systemic routes like tail vein injection to achieve targeted gene knockdown in relevant tissues, particularly the liver and intestine. It is primarily used as a laboratory reagent and has no known clinical development.