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AAV9-Glp1r-shRNA
- Development stage
- Preclinical
- Lead developer
- Genechem
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
AAV9-Glp1r-shRNA is a research-grade gene therapy tool designed for the targeted knockdown of the glucagon-like peptide-1 receptor (GLP-1R) in vivo. It utilizes an adeno-associated virus serotype 9 (AAV9) vector to deliver a short hairpin RNA (shRNA) sequence specific to the mouse *Glp1r* gene. Primarily used in preclinical mouse models, such as DSS-induced chronic colitis, the construct is typically administered intravenously to investigate the role of GLP-1R signaling in metabolic, epigenetic, and fibrotic processes. It was custom-manufactured by Genechem (Shanghai, China) and serves as a laboratory reagent rather than a clinical therapeutic candidate.
- Other names
- AAV9-Glp1r-shRNAAAV-9-Glp1r-shRNAAAV 9-Glp1r-shRNAAAV9-sh-Glp1rAAV-9-sh-Glp1rAAV 9-sh-Glp1rAAV9-shGlp1rAAV-9-shGlp1rAAV 9-shGlp1r
02
Targets
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