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AAV9-IL1B
- Development stage
- Preclinical
- Lead developer
- University of California, San Francisco
- Modality
- Gene Therapies
- Administration
- Intratumoral
01
Overview
AAV9-IL1B is an experimental gene therapy consisting of an adeno-associated virus serotype 9 (AAV9) vector encoding the cytokine interleukin-1 beta (IL-1β). Developed by researchers at the University of California, San Francisco (UCSF), it is designed for the treatment of glioblastoma via convection-enhanced delivery (CED). The therapy functions by reprogramming the immunosuppressive glioblastoma microenvironment, promoting the recruitment and activation of anti-tumor immune cells such as CD8+ T cells, macrophages, and microglia. Additionally, AAV9-IL1B treatment has been shown to suppress pro-tumorigenic cytokines, specifically IL-6, thereby attenuating tumor growth and improving survival in preclinical models.
- Other names
- AAV9-Il1bAAV-9-Il1bAAV 9-Il1b
02
Targets
IL1R2 (Interleukin-1 receptor type II)IL1R1 (Interleukin-1 Receptor Type 1)
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