AAV9-luciferase

AAV9-luciferase is a preclinical research tool consisting of an adeno-associated virus serotype 9 (AAV9) vector engineered to express the firefly luciferase reporter protein. It is primarily used in bioluminescence imaging (BLI) to monitor gene delivery efficiency, tissue-specific transduction, and the long-term biodistribution of AAV9-based gene therapies in vivo. By measuring the light emitted upon the administration of a luciferin substrate, researchers can non-invasively track the expression of the transgene across various tissues, including the liver, heart, skeletal muscle, and central nervous system. While not a therapeutic agent, it serves as a critical benchmark for optimizing vector dosing and evaluating potential toxicities, such as pulmonary endothelial expression or cytokine activation, in animal models of diseases like Duchenne muscular dystrophy (DMD).

Other names

AAV9-luciferase reporter vectorAAV-9-luciferase reporter vectorAAV 9-luciferase reporter vectorAAV9-firefly luciferaseAAV-9-firefly luciferaseAAV 9-firefly luciferase