AAV9-shCon

AAV9-shCon is a research-grade viral vector used as a negative control in gene silencing experiments, particularly those involving RNA interference (RNAi). It consists of an adeno-associated virus serotype 9 (AAV9) capsid packaging a genetic payload that expresses a non-targeting, or 'scrambled,' short hairpin RNA (shRNA). AAV9 is a widely utilized vector in neuroscience due to its ability to cross the blood-brain barrier and efficiently transduce various CNS cell types, including neurons and astrocytes. In preclinical models of Alzheimer's disease and neurovascular dysfunction, AAV9-shCon serves as a critical baseline to control for the biological effects of viral transduction and shRNA expression, allowing researchers to isolate the specific effects of knocking down a target gene, such as Endoglin (ENG).

Other names

AAV9-scrambled-shRNAAAV-9-scrambled-shRNAAAV 9-scrambled-shRNAAAV9-non-targeting-shRNAAAV-9-non-targeting-shRNAAAV 9-non-targeting-shRNA