AAVNPY

AAVNPY is an **adeno-associated viral (AAV) vector-based gene therapy** encoding the gene for **neuropeptide Y (NPY)**. It is developed for **CNS delivery to overexpress NPY**, particularly in the brain and hypothalamic regions, and has been studied mainly for its potential to modulate neuronal activity, suppress seizures, and stimulate autophagy in animal models. The mechanism centers around increasing endogenous NPY levels in targeted CNS regions, leading to **anticonvulsant effects in epilepsy models** and enhanced autophagic flux in hypothalamic neurons. Studies demonstrate that AAVNPY administered via intracerebral injection produces sustained high NPY expression and correlates with significant seizure reduction and autophagy-associated protein turnover in rodents.

Other names

AAV-NPYrAAV-NPYadeno-associated viral vector encoding neuropeptide Y