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AB-110 + unmanipulated umbilical cord blood
- Development stage
- Unknown
- Lead developer
- Angiocrine Bioscience
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
AB-110 + unmanipulated umbilical cord blood is a combination cell therapy regimen developed by Angiocrine Bioscience for the treatment of high-risk hematologic malignancies. AB-110 consists of hematopoietic stem and progenitor cells (HSPCs) that have been expanded ex vivo using Angiocrine's proprietary E-CEL (Engineered Colony-forming Endothelial Cells) technology. This technology utilizes human umbilical vein endothelial cells (HUVECs) genetically modified with the adenovirus E4ORF1 gene, which allows the cells to survive and function as a supportive vascular niche without exogenous growth factors. In clinical practice, the expanded AB-110 product is co-infused with a standard, unmanipulated umbilical cord blood unit. The expanded cells in AB-110 are designed to provide rapid, short-term hematopoietic recovery (neutrophils and platelets), while the unmanipulated unit ensures long-term engraftment and immune reconstitution.
- Other names
- E-CELVeraCellE-CEL UVEC expanded cord bloodE4ORF1-engineered endothelial cell expanded cord bloodE-4ORF1-engineered endothelial cell expanded cord bloodE 4ORF1-engineered endothelial cell expanded cord blood
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